Methyl ethyl ketone health effects, Methyl ethyl ketone (MEK) Revision Date 02/25/2021 Version 2. Thirty-five workers were selected from a two-stage field _I. Download The known health effects to people from exposure to butanone are irritation of the nose, throat, skin, and eyes. We recently demonstrated that other ketone bodies, methyl ethyl ketone (MEK) and diethyl ketone (DEK), suppressed status epilepticus that was induced by lithium-pilocarpine in rat. Chronic inhalation exposure may have hazardous health effects in the form of the liver, kidney, respiratory and neurological damage. A. Several are CNS depressants, and the purpose of this experiment was to assess the behavioral effects of 4-hour inhalation exposures to two solvents, toluene and methyl ethyl ketone (MEK) alone and combined. 2-Butanone is used in a number of industrial products such as paints and other coatings. Methyl ethyl ketone (MEK) and white spirit . a broad class of health effects that range from Methyl Ethyl Ketone (MEK), also known as butanone, is an organic chemical with the formula CH3C (O)CH2CH3. S. The kinetics of inhaled methyl ethyl ketone (MEK) at a concentration of 200 ppm for four hours were studied in volunteers after swallowing ethanol at a dose of 0. MEK, 2-BUTANONE, 2-BUTANONE (MEK), BUTANONE, MEK, and METHYL ETHYL KETONE. Animal studies have reported slight neurological, liver, kidney, and respiratory effects from chronic exposure to methyl ethyl ketone. Methyl Ethyl Ketone Peroxide (MEKP) is a highly toxic clear liquid used as a solvent. Symptoms may include Skin Contact: May cause mild irritation. If you touch methyl ethyl ketone, take off your clothes. In Section 6, EPA has characterized its overall confidence in the quantitative and qualitative aspects of hazard and dose Studies of the health effects of MEKP are limited and primarily focus on short-term exposures to relatively large amounts of the chemical. (1) Health Hazard Information Acute Effects: * Acute exposure of humans to high concentrations of methyl ethyl ketone produces irritation to the eyes, nose, and throat. Download Health safety: Methyl ethyl ketone can have toxic effects if inhaled or swallowed. It can be produced in the outdoor air by the photo-oxidisation of butane. 92-463 of 1972, the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances (NAC/AEGL Committee) has been established to identify, review, and interpret relevant toxicologic and other scientific data and develop AEGLs for In similar tests of subclinical neurobehavioral performance, statistically significant effects were observed in only 4 of 32 measures in 68 male and 75 female volunteers exposed for 4 h to 200 ppm of MEK vapors, 100 ppm of methyl isobutyl ketone (MIBK), a mixture of 100 ppm of MEK and 50 ppm of MIBK, or a placebo, but the magnitude of the Methyl ethyl ketone can be found in both indoor and outdoor air. Wash yourself with soap and water. com info@parchem. PREFACE. I. May cause severe eye and skin irritation with possible burns. May cause fetal effects. The repeated exposure to the skin can remove the fats and oils, causing dermatitis. Chronic inhalation studies in animals have reported slight neurological, liver, kidney, and respiratory effects. 8 g/kg. On March 30, 1998, EPA denied the petition based on the conclusion that Volatile Organic Compounds (VOCs), such as MEK, contribute to the formation of tropospheric ozone which is known to cause significant adverse effects to human health and the environment. Methyl ethyl ketone (MEK), also known as butanone, is an organic compound with the molecular formula CH3C(O)CH2CH3. About the Chemical. This colourless liquid ketone has a sharp, sweet odour reminiscent of butterscotch and acetone. Does methyl ethyl ketone affect pregnancy or the unborn child? There are limited data available on the direct effects of exposure to methyl ethyl ketone during pregnancy. for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to methyl ethyl ketone. This dialkyl ketone is a colourless liquid that has a sharp and sweet odour. It is partially soluble in water, and is commonly used as an industrial Overview Health effects Environmental effects Sources of emissions References Description Methyl ethyl ketone is used as a solvent for lacquers, adhesives, cleaning materials to be electroplated, degreasing, rubber and rubber cement, printing inks, and paints, wood stains and varnishes, paint removers, in cleaning solutions, as a catalyst, and as a carrier. Summary of Health Effects . Product and Company Identification Product Name Methyl Ethyl Ketone CAS Number 78-93-3 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem. Contributor(s): World Health Organization | International Programme on Chemical Safety Material type: Text Series: Environmental health criteria ; 143 Publication Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure. 35 °C and 79. Therefore, it is not possible to draw any definitive conclusions. Workers may be harmed from exposure to methyl ethyl ketone. Use Understanding methyl ethyl ketone health effects can be vital if you were not provided with the correct protective equipment. MayAcute effects be Product name Methyl ethyl ketone (MEK) Chemical name Methyl ethyl ketone Synonyms butan-2-on, 2-butanon, Ethyl methyl ketone REACH Reg. Due to the lack of available data, U. If you use assistive technology * Breathing Methyl Ethyl Ketone can irritate the nose and throat causing coughing and wheezing. Causes eye irritation. Irritates the Eyes – Can cause irritation or serious damage to the eye. These effects are not expected to occur at levels of MEK that are normally found in the environment. 78-93-3 EC no. The specific gravity of MEK at 20°C/4°C is 0. It can also be present in the environment from natural sources. Methyl Ethyl Ketone (MEK), also known as butanone, is an organic chemical with the formula CH3C (O)CH2CH3. Get medical help right away. 3 Methyl Ethyl Ketone 1. 2-Butanone is also called methyl ethyl ketone. Harmful if swallowed - may enter lungs if swallowed or vomited. 2-Butanone, 3-Butanone, methyl acetone, Ethyl methyl ketone . Chronic (Long Term) Effects Methyl ethyl ketone is used as a solvent. Effects Of Methyl Ethyl Ketone is a colorless liquid used as a solvent, adhesive, and cleaning agent. MEK is flammable and its flash point is 16°F or -9°C (Merck Index 1983, Toxicology Data Bank 1985). Contributor(s): World Health Organization | International Programme on Chemical Safety Material type: Text Series: Environmental health criteria ; 143 Publication MEK is an aliphatic ketone. IDENTIFICATION PRODUCT NAME: METHYL ETHYL KETONE SYNONYM: 2-BUTANONE, MEK CHEMICAL FORMULA:C4H8O 2. Relevant identified uses of the substance or mixture and uses advised against Slight neurological, liver, kidney, and respiratory effects have been reported in chronic inhalation studies of methyl ethyl ketone in animals. Harmful if inhaled. Contributor(s): World Health Organization | International Programme on Chemical Safety Material type: Text Series: Environmental health criteria ; 143 Publication Overview Health effects Environmental effects Sources of emissions References Description Methyl ethyl ketone is used as a solvent for lacquers, adhesives, cleaning materials to be electroplated, degreasing, rubber and rubber cement, printing inks, and paints, wood stains and varnishes, paint removers, in cleaning solutions, as a catalyst, and as a carrier. Methyl ethyl ketone is used in many industries. It is produced industrially on a large scale, but occurs in nature only in trace amounts. Thirty-five workers were selected from a two-stage field 3 Methyl Ethyl Ketone 1. Acute health effects From MSDS: Emergency Overview High vapor concentrations can irritate eyes, nose and respiratory passages. Functions. Studies of the health effects of MEKP are limited and primarily focus on short-term exposures to relatively large amounts of the chemical. com EMERGENCY RESPONSE NUMBER CHEMTEL Product name METHYL ETHYL KETONE CAS-No. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD) Substance Name -- Methyl ethyl ketone (MEK) CASRN -- 78-93-3 Last Revised -- 05/01/1993 The oral Reference Dose (RfD) is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. At high concentrations: can harm the nervous system. May affect the brain or nervous system causing dizziness, headache or nausea. Chronic Health Effects The following chronic (long-term) health effects can occur at some time after exposure to Methyl Ethyl Ketone and can last for months or years: Cancer Hazard Limited information is available on the chronic (long-term) effects of methyl ethyl ketone in humans. John Bucher. Rats and mice exposed to MEKP (45% in dimethyl phthalate) on their skin for two and thirteen weeks developed a spectrum of necrotic, inflammatory, and regenerative lesions at the application site. Methyl ethyl ketone (MEK) Synonyms. PDF, 35. Can be absorbed through the skin, but harmful effects are not expected. [5] Methyl ethyl ketone / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. How is MEK used? MEK is made by humans, but also exists naturally in the environment. EPA has classified methyl ethyl ketone as a Group D, not classifiable as to human carcinogenicity. 00 Hours Acute Oral LD50 Rat: 2300 mg/kg Sensitization Not a skin sensitizer. What factors limit use or exposure to methyl ethyl ketone? At work, safe work methods limit exposure. 2 Relevant identified uses of the substance or mixture and uses advised against Identified uses Chemical for analysis and production 1. It can be harmful to the eyes, skin, and if inhaled or swallowed. Sources Methyl Ethyl Ketone is a colorless liquid used as a solvent, adhesive, and cleaning agent. the throat. It is a man-made chemical and while it can also be found in nature, MEK inhalation creates eyes, nose, and throat irritation. Butanone, also known as ethyl methyl ketone, is an organic compound with the formula CH 3 C (O)CH 2 CH 3. Chronic Health Hazard Assessments for Noncarcinogenic Effects . Irritates the Skin – Can cause irritation or serious damage to the skin. Acute Effects [3] METHYL ETHYL KETONE (78-93-3) Acute Dermal LD50 Rabbit: > 8000 mg/kg Acute Dermal LD50 Rat: 4680 mg/kg Acute Inhalation LC50 Rat: 11700 mg/l 4. 6 mm Hg. Causes nose and throat irritation. Non-reproductive organ system toxicity (high) and Irritation (skin, eyes, or lungs) (high) fragrance ingredient, solvent, and perfuming. In Section 6, EPA has characterized its overall confidence in the quantitative and qualitative aspects of hazard and dose Jersey Department of Health, Methyl Ethyl Ketone Peroxide has not been tested for its ability to affect reproduction. The summaries presented in If you touch methyl ethyl ketone, take off your clothes. In this paper we present a case of a young patient The melting and boiling points of MEK are -86. 1. Methyl ethyl ketone: general information. Under the authority of the Federal Advisory Committee Act (FACA) P. Ingestion is associated with corrosive burns leading to stricture formation, inhalational pneumonitis, acidosis, liver failure and renal failure. g dichlormethane : Ketones e. Limited information is available on the chronic (long-term) effects of methyl ethyl ketone in humans. Effects on METHYL ETHYL KETONE: ICSC: 0179 (April 2017) Ethyl methyl ketone 2-Butanone MEK Methyl acetone: CAS #: 78-93-3: EXPOSURE & HEALTH EFFECTS; Routes of exposure Male: Negative. Flash Point: -7˚ C. It is made by some trees and found naturally in some fruits and vegetables in small amounts. MayAcute effects be _I. Direct, prolonged contact with liquid methyl ethyl ketone irritates the skin and damages the eyes. It is a strong oxidizing agent and a corrosive. It is used as a solvent in acrylic coatings, adhesives, paint The melting and boiling points of MEK are -86. Acute Exposure Guideline Levels. 6°C, respectively; its vapor pressure at 20°C is 70. Repeated exposure may cause bronchitis to develop with coughing, phlegm, and/or shortness of breath. Product Name: Methyl Ethyl Ketone Peroxide, DDM-9, Hipoint 90, MEKP-9 Components CAS Number Typical % OSHA Methyl Ethyl Ketone Peroxide 1338-23-4 32-34 y Hexylene Glycol 107-41-5 6% y 2,2,4-trimethyl-1,3pentanediol,diisobutyrate 6846-50-0 58% y Hydrogen Peroxide 7722-84-1 < 1% y Methyl Ethyl Ketone 78-93-3 < 2% y Methyl ethyl ketone / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. Ethanol was (Methyl Ethyl Ketone) DATE PREPARED: 6/19/2015 Page 1 of 8 Section 1. Acute (Short Term) Effects Toxic to Humans & Animals – Can be fatal on contact, ingestion or inhalation for humans and other mammals. Other Effects f Methyl Ethyl Ketone Peroxide can irritate the lungs. (1,4) * Other effects reported from acute inhalation exposure in humans include central nervous system depression, headache, and nausea. * Exposure can cause dizziness, lightheadedness, headache, nausea, blurred vision, and may cause you to pass out. Cardiac arrhythmia (high Methyl ethyl ketone / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. In the present study, th … for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to methyl ethyl ketone. 9 KB, 4 pages. Acute effects Harmful if inhaled. If you get methyl ethyl ketone in your eyes, flush with clean water for up to 15 minutes. Cancer . HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Appearance: colorless liquid. METHYL ETHYL KETONE 1. 41 IPCS 1993 Melting Point -86°C ACGIH 2001 Studies of the health effects of MEKP are limited and primarily focus on short-term exposures to relatively large amounts of the chemical. 201-159-0 Index no. It is produced industrially on a large scale, and also occurs in trace amounts in nature. This colorless liquid ketone has a sharp, sweet odor reminiscent of butterscotch and acetone. Flammable liquid and vapor. g (MEK), Dermatitis : Dizziness, drowsiness and other effects on the central nervous system . EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development. Harmful if swallowed. Methyl ethyl ketone (MEK); CASRN 78-93-3; 00/00/00 Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of chronic toxicity data by U. It acts as a bacterial metabolite and polar aprotic solvent. 01-2119457290-43-0000 CAS no. Following the denial, the American Chemistry Council (formerly CMA) filed suit This study investigated the effects of different levels of N,N-dimethylformamide (DMF) and co-exposure levels of methyl ethyl ketone (MEK) and toluene (TOL) on two biomarkers of DMF exposure: non-metabolized urinary (U-)DMF and the DMF metabolite urinary N-methylformamide (NMF). Contributor(s): World Health Organization | International Programme on Chemical Safety Material type: Text Series: Environmental health criteria ; 143 Publication Ketones, such as methyl ethyl ketone depress the central nervous system, irritate the eyes and upper respiratory tract. It is also Dizziness, drowsiness and other effects on the central nervous system : Lithographic blanket restorers, cleaning solvents. It Jersey Department of Health, Methyl Ethyl Ketone Peroxide has not been tested for its ability to affect reproduction. 78-93-3 Product code AR1122, EP1122, GP1122, LC1122, RP1122, XP1122 1. The Office of Emergency and Remedial Response (Superfund) uses these documents in preparing cost-benefit analyses under Executive Order 12991 for decision-making under CERCLA. If Studies of the health effects of MEKP are limited and primarily focus on short-term exposures to relatively large amounts of the chemical. 08% blood levels was used as a positive control. (wikipedia); Butanone, better known as methyl ethyl ketone or MEK, is an organic compound with the formula CH3C (O)CH2CH3. A Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure. Download This study investigated the effects of different levels of N,N-dimethylformamide (DMF) and co-exposure levels of methyl ethyl ketone (MEK) and toluene (TOL) on two biomarkers of DMF exposure: non-metabolized urinary (U-)DMF and the DMF metabolite urinary N-methylformamide (NMF). 2. No. 805 and its vapor density is 2. Methyl ethyl ketone / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. 0 Print Date 02/25/2021 110000000947 Page 1 of 10 SAFETY DATA SHEET SECTION 1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING . Acute and chronic toxicity can occur as an occupational hazard. SARA 311 Fire Hazard, Acute Health Hazard, Chronic Health Hazard SARA 312 Fire Hazard, Acute Health Hazard, Chronic Health Hazard SARA 313 Listed: Methyl Ethyl Ketone WHMIS Canada Class B-2: Flammable and combustible liquid- Flammable liquid 16. How can this chemical affect my health? Acute (Short Term) Effects Toxic to Humans & Animals – Can be fatal on contact, ingestion or inhalation for humans and other mammals. Mammalian Cell Mutagenicity. Acute (short-term) inhalation exposure to methyl ethyl ketone in humans results in irritation to the eyes, nose, and throat. The level of exposure depends upon the dose, duration, and work being done. Reference Dose for Chronic Oral Exposure (RfD) Substance Name — Methyl ethyl ketone (MEK) CASRN — 78-93-3 Last Revised — 09/26/2003 The oral Reference Dose (RfD) is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. 5 mm Hg at 20°C ACGIH 2001 Relative Vapor Density (air = 1) 2. Ethanol was 2-Butanone is an industrial chemical. 26 TRRP 2006 Vapor Pressure 77. Health Effects Methyl ethyl ketone poisoning affects a range of systems including the respiratory, nervous and blood systems. An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Methyl ethyl ketone peroxide (1338-23-4). Chlorinated hydrocarbons e. Contributor(s): World Health Organization | International Programme on Chemical Safety Material type: Text Series: Environmental health criteria ; 143 Publication Organic solvents are used frequently in industry and workers are often exposed to various combinations of these chemicals. a broad class of health effects that range from Methyl Ethyl Ketone (MEK) C 4H 8O . This colourless liquid ketone has a sharp, sweet odor reminiscent of acetone. If inhaled for a short time, it can lead to the irritation of the upper respiratory passages, throat and conjunctive. Female: Negative. Ethanol at 0. No information is available on the developmental, reproductive, or carcinogenic effects of methyl ethyl ketone in humans. GOV Technical Report: Health and environmental-effects profile for methyl ethyl ketone The report summarizes and evaluates information relevant to a preliminary interim assessment of adverse health effects associated with specific chemicals or compounds. Methyl Ethyl Ketone is a dialkyl ketone which consists of 4 carbon ketone that carries a single keto group at the C-2 position. Use Methyl ethyl ketone / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. Methyl ethyl ketone (C 4 H 8 O or CH 3 CH 3 COCH 2 CH 3) is a colorless, flammable liquid with a sharp odor. [5] Abstract. chronic (long-term) exposure to methyl ethyl ketone in humans. It is used as a solvent in acrylic coatings, adhesives, paint Compendium of Chemical Hazards: Methyl Ethyl Ketone Page 8 of 14 Incident Management Health Effects Major route of exposure inhalation, ingestion and skin contact Immediate signs or symptoms of acute exposure Route Signs and symptoms Inhalation Inhalation of high concentrations may cause respiratory irritation and chest tightness. However, due to its various applications, the industrialists produce this chemical on a large scale. The compound has also been found in drinking and surface water. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of methyl ethyl ketone. OTHER INFORMATION Revision Date Revision 1 08-10-2011 Revision 2 08/05/2013 Abstract. Human health effects associated with breathing or otherwise consuming smaller amounts of methyl ethyl ketone over long periods of time Methyl ethyl ketone / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. This file may not be suitable for users of assistive technology. OSTI. (METHYL ETHYL KETONE (MEK)) PAGE 4 of 10 8 – EXPOSURE CONTROLS / PERSONAL PROTECTION OCCUPATIONAL EXPOSURE LIMITS HAZARDOUS INGREDIENT PEL TLV-TWA Methyl ethyl ketone (MEK) 200 ppm 200 ppm EXPOSURE CONTROLS: Good general ventilation (typically 10 air changes per hour) should be used. L. What are the potential health effects of methyl ethyl ketone? Inhalation: Can irritate the nose and throat. 92-463 of 1972, the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances (NAC/AEGL Committee) has been established to identify, review, and interpret relevant toxicologic and other scientific data and develop AEGLs for In similar tests of subclinical neurobehavioral performance, statistically significant effects were observed in only 4 of 32 measures in 68 male and 75 female volunteers exposed for 4 h to 200 ppm of MEK vapors, 100 ppm of methyl isobutyl ketone (MIBK), a mixture of 100 ppm of MEK and 50 ppm of MIBK, or a placebo, but the magnitude of the METHYL ETHYL KETONE (78-93-3) Acute Dermal LD50 Rabbit: > 8000 mg/kg Acute Dermal LD50 Rat: 4680 mg/kg Acute Inhalation LC50 Rat: 11700 mg/l 4. 606-002-00-3 Article no. Organic solvent exposure prevention starts with performing a hazard evaluation. 18000000 1. Trade name. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS __I. 3 Details of the supplier of the safety data sheet Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure. f Methyl Ethyl Ketone Peroxide may cause a skin allergy. Request an accessible format. METHYL ETHYL KETONE: ICSC: 0179 (April 2017) Ethyl methyl ketone 2-Butanone MEK Methyl acetone: CAS #: 78-93-3: EXPOSURE & HEALTH EFFECTS; Routes of exposure What is Methyl Ethyl Ketone (Butanone)? Methyl Ethyl Ketone is an organic compound which is also known as Butanone or Methylacetone. Methyl Ethyl Ketone (MEK) C 4H 8O . It occurs in nature in a small amount. Tools: What is Methyl Ethyl Ketone (Butanone)? Methyl Ethyl Ketone is an organic compound which is also known as Butanone or Methylacetone. Skip to main On this website we use cookies and similar technology to collect and analyse information about visitors to this website. Synonyms. Methyl ethyl ketone (MEK) can affect the reproductive system of animals and may affect how unborn babies develop. Slight neurological, liver, kidney, and respiratory effects have been reported in chronic inhalation studies of methyl ethyl ketone in animals. Understanding methyl ethyl ketone health effects can be vital if you were not provided with the correct protective equipment. Toxicology, 2008. Danger! May cause respiratory tract irritation. MEK is an aliphatic ketone. [3] , [4] MEK has been reported to cause peripheral and central neurotoxicity following long-term exposure. 41 (Air = 1). The anticonvulsant effects of acetone have been reported in various animal models of epilepsy. Methyl ethyl ketone is not thought to be a cancer causing chemical. Download . If Synonyms 2-Butanone; MEK; Methyl ethyl ketone; Methylethyl ketone; Acetone, methyl-; Ethyl methyl ketone; Methyl acetone ChemID Plus 2009 Solubility in water 223 g/L ChemID Plus 2009 Log K ow 0. This is a solvent commonly found in one-component silicone sealants.


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